منابع مشابه
Marginal zone lymphomas: management of nodal, splenic, and MALT NHL.
Marginal zone lymphomas are indolent B-cell lymphomas that originate from the marginal zone of B-cell follicles. For several subtypes, the initiation of disease appears to be a consequence of chronic infection and/ or inflammation. While the initial lymphoid hyperplasia is driven by physiologic antigenic stimulation, additional oncogenic events, such as chromosomal translocations leading to con...
متن کاملKaryometric Comparison of Splenic and Gastric Marginal Zone Lymphomas
BACKGROUND Marginal zone lymphomas are indolent B-cell lymphomas associated with autoimmunity and chronic inflammation. The two most frequent variants are mucosa associated lymphoid tissues marginal zone lymphomas and splenic marginal zone lymphomas. The aim of the study was to determine if it is possible to classify splenic and gastric lymphomas according to karyometric features. METHODS The...
متن کاملSplenic marginal zone lymphomas with peripheral CD5 expression.
We report 4 cases of splenic marginal zone lymphoma (SMZL) with peripheral CD5 positive, B-cell lymphocyto-sis. This unusual immunophenotypic discordance raises dilemmas in the diagnostic approach of these patients. In addition, this association may be related to a more aggressive clinical course, as 3 out of 4 of our patients died from progressive disease. Splenic marginal zone lymphoma (SMZL)...
متن کاملSplenic marginal zone lymphoma.
Splenic marginal zone lymphoma (SMZL) is a specific low-grade small B-cell lymphoma that is incorporated in the World Health Organization classification. Characteristic features are splenomegaly, moderate lymphocytosis with villous morphology, intrasinusoidal pattern of involvement of various organs, especially bone marrow, and relative indolent course. Tumor progression with increase of blasti...
متن کاملNon-MALT marginal zone lymphomas.
The concept of marginal zone B-cell lymphomas was developed in the 1990s for lymphomas whose cells originate from B lymphocytes normally present in a distinct anatomical location, the so-called ‘marginal zone’ (MZ). MZ has been described in the lymphoid organs—spleen and lymph nodes—and in nonlymphoid organs—mucosa-associated lymphoid tissue (MALT) or non-mucosal tissue such as skin, orbit and ...
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ژورنال
عنوان ژورنال: The American Journal of Pathology
سال: 1999
ISSN: 0002-9440
DOI: 10.1016/s0002-9440(10)65327-8